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KMID : 1034720140060010011
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Journal of Neurosonology and Neuroimaging
2014 Volume.6 No. 1 p.11 ~ p.15
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Relationship Between Transcranial Doppler Pulsatility Index and Cerebral White Matter Hyperintensities
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Han Sang-Won
Song Tae-Jin
Lee Seong-Soo
Kim Seo-Hyun
Lee Jun-Hong
Kim Gyu-Sik
Kim Ok-Joon
Koh Im-Seok
Lee Jong-Yun
Suk Seung-Han
Lee Sung-Ik
Nam Hyo-Suk
Kim Won-Joo
Lee Kyung-Yul
Park Joong-Hyun
Kim Jeong-Yeon
Park Jae-Hyeon
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Abstract
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Background: The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of the Transcranial Doppler (ECLIPse) study showed a significant decrease in the transcranial Doppler (TCD) pulsatility index (PI) with cilostazol treatment at 90 days after acute lacunar infarction. The aim of the present study was to perform a subgroup analysis of the ECLIPse study in order to explore the relationship between TCD PI and cerebral white matter hyperintensities (WMH) volume in acute lacunar infarction.
Methods: For this subgroup analysis, WMH volume was measured for those subjects for whom fluid-attenuated inversion recovery (FLAIR) images were available using semi-automated computerized software.
Results: Of the 203 patients in eight hospitals in the ECLIPse study, 130 participants from six hospitals were included in this subgroup analysis. The mean WMH volume was 11.57 cm3 (0.13 to 68.45, median 4.86) and the mean MCA PI was 0.95 (0.62 to 1.50). The WMH volume was strongly correlated with age (r=0.388, p<0.001) and mMCA PI (r=0.178, p=0.043). Multiple linear regression analysis revealed that age (p<0.001, β coefficient=0.384) was significantly associated with WMH volume.
Conclusions: Though multiple linear regression analysis revealed that only age was significantly associated with WMH volume, our findings indicate that TCD PIs are elevated when small vessel disease (SVD) is present. These parameters may be a useful physiologic index of the presence and severity of SVD. Further clinical trials focusing on WMH volume and clinical outcomes are required to assess the TCD as a screening tool for SVD.
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KEYWORD
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Lacunar infarcts, Pulsatility index, White matter hyperintensities
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